Longevity

A proved lifestyle that extends your maximum life span

My Longevity Secrets

My best kept Top-Secrets

Eliecer Alberto Velasco BS, MSc Chronological Age: 63 years Biological Age: 46 years

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My First Secret

Daily Nutritional Supplement with: N-acetyl Carnosine and Astragalus extract

Reach the"Hayflick Limit" and live more than 120 years old

The "Hayflick limit" is the number of times a cell will divide before it stops due to the telomere reaching a critical length

It was discovered by Leonard Hayflick in 1965, when Hayflick demonstrated that normal human cells in a cell culture divide about 52 times before entering a senescence phase (refuting the contention by Alexis Carrel that normal cells are (immortal). Each mitosis shortens the telomere appendix on the DNA of the cell, thus ticking back an "inner clock" for each subsequent copy of the cell.[1]

This mechanism is believed to have evolved primarily to protect the body from creating a potentially-cancerous cell. Because of the fragmented way DNA replicates, a very short telomered cell may lead to genomic instability when the proteins meant to be located on the telomere will fail to attach and it will be marked as a double-strand DNA break.

Many stem cells, as they are undifferentiated, are not affected by the Hayflick limit. They exist in every tissue and may continue reproducing for the lifespan of the organism. To avoid reaching the barrier, cells that need to keep on dividing express the telomerase enzyme or use Alternative Lengthening of Telomeres mechanism.

The normal Hayflick limit of cells in organisms other than humans varies, and affects their life span.

Carnosine can increase the Hayflick limit in human, It appears to reduce the telomere shortening rate.

Two weeks using telomerase activation with astragalosides,
This procedure is expected to produce telomere elongations of less than 38 base pairs per month, that is, less than 456 base pairs/year. About 50-200 telomere base pairs are typically lost per cell division, although antioxidants may reduce the loss rate. Humans have about 50 cell divisions available from the embryonic stage of development, so this procedure may outdistance the aging process, although treatment should continue for years. TA Sciences does as well as the maximum here in blood granulocytes, 230 base pairs during each 3-month telomerase-on pulse in the Patton protocol using TA-65, which is probably cycloastragenol. This corresponds to a rejuvenation rate of about 9 years backwards in time per year.
GAIA Extra Strength Astragalaus Extract, 77 drops/5 mg of, 5 mg/day, or regular GAIA Astragalaus extract, 150 drops/5 mg of astrogalosides, 5 mg/day.

Furthermore, it has been noted that Astragaloside IV bioavailability is improved by the addition of some powdered astragalus membranaceus root, so that an astragalus root powder capsule may be a useful supplement to our program. I might add that astragalus extract also contains Astragaloside VII, which markedly boosts the levels of Interleukin-2, also a useful telomerase activator for immune system T-cell lymphocytes. GAIA makes other astragaloside-specific astragalus extracts that may be used, including their standard Astragalus Extract and astragalus extract in glycerin. Available astragalus extract pills typically feature 1 mg astragalosides per 250 mg of extract.

Michael Fossel, Cells, Aging, and Human Disease, p.160. notes that among progerics, whose fibroblasts exhibit short telomeres, baldness is almost universal. My impression today is that telomerase activation is crucial for long-range life extension.

In treatment with telomerase activators, skin constitution is restored to young skin after about 20 population doublings are added. Note that TA Science's TA-65 (probably cycloastragenol) can add 230 base pairs to blood granulocyte telomeres in vivo in just 3 months. For typical cells on the average, 20 doubling x 50(bp/doubling) = 1000 base pairs, so that a couple of years would be typically required, since telomerase is turned on for just two 3-month periods in a year using the TA Sciences Patton Protocol. That is, they get 460 bp/year, so that 1000/460 = 2.174 > 2 years should be required to thoroughly rejuvenate typical cells with TA-65. Furthermore, we loose about 50 bp per year to normal attrition as our cells divide year by year, so over 2 years of treatment we need to tack on 100 bp just to keep up with aging. Thus about 11000/460 = 2.3913 > 2 years is a rough guide to what to expect. After 3 or 4 years of plenty of astragaloside application, we should probably expect to have achieved serious rejuvenation effects. Since 460 >> 50, we may seem to feel the second hand of the clock running backwards with TA-65 at about 9 years per year. Initial measurements seem to show that good results can be achieved with commercially available astragalus extracts in alcohol and glycerine. A chart of the count of grey hairs on the head was used, as the greying is regarded by Geron as a sign of stem cell dysfunction reversible with telomerase activation, and may follow the death rate curve mirroring the general level of the senescent cell population.
Since carnosine can change the cellular phenotype from senescent to normal, perhaps carnosine should be used together with astragaloside treatments for lengthening telomeres. Our objective is to rejuvenate senescent cells.

My 2nd. Secret

Stop-Trans-Fat

No Trans Fat Organization

The greatest exponent of monounsaturated fat is olive oil, and it is a prime component of the Mediterranean Diet. Olive oil is a natural juice which preserves the taste, aroma, vitamins and properties of the olive fruit. Olive oil is the only vegetable oil that can be consumed as it is - freshly pressed from the fruit.

The beneficial health effects of olive oil are due to both its high content of monounsaturated fatty acids and its high content of antioxidative substances. Studies have shown that olive oil offers protection against heart disease by controlling LDL ("bad") cholesterol levels while raising HDL (the "good" cholesterol) levels. (1-3) No other naturally produced oil has as large an amount of monounsaturated as olive oil -mainly oleic acid.

Olive oil is very well tolerated by the stomach. In fact, olive oil's protective function has a beneficial effect on ulcers and gastritis. Olive oil activates the secretion of bile and pancreatic hormones much more naturally than prescribed drugs. Consequently, it lowers the incidence of gallstone formation.

Olive oil and heart disease

Studies have shown that people who consumed 25 milliliters (mL) - about 2 tablespoons - of virgin olive oil daily for 1 week showed less oxidation of LDL cholesterol and higher levels of antioxidant compounds, particularly phenols, in the blood.(4)

But while all types of olive oil are sources of monounsaturated fat, EXTRA VIRGIN olive oil, from the first pressing of the olives, contains higher levels of antioxidants, particularly vitamin E and phenols, because it is less processed.

Olive oil is clearly one of the good oils, one of the healing fats. Most people do quite well with it since it does not upset the critical omega 6 to omega 3 ratio and most of the fatty acids in olive oil are actually an omega-9 oil which is monounsaturated.

Olive oil and colon cancer

Spanish researchers suggest that including olive oil in your diet may also offer benefits in terms of colon cancer prevention (5). Their study results showed that rats fed diet supplemented with olive oil had a lower risk of colon cancer than those fed safflower oil-supplemented diets. In fact, the rats that received olive oil had colon cancer rates almost as low as those fed fish oil, which several studies have already linked to a reduction in colon cancer risk.

Types of olive oil

Generally, olive oil is extracted by pressing or crushing olives. Olive oil comes in different varieties, depending on the amount of processing involved. Varieties include:

When buying olive oil you will want to obtain a high quality EXTRA VIRGIN oil. The oil that comes from the first "pressing" of the olive, is extracted without using heat (a cold press) or chemicals, and has no "off" flavors is awarded "extra virgin" status. The less the olive oil is handled, the closer to its natural state, the better the oil. If the olive oil meets all the criteria, it can be designated as "extra virgin".

What is pure and light olive oil? "Pure" olive oil is made by adding a little extra virgin olive oil to refined olive oil. It is a lesser grade oil that is also labeled as just "olive oil" in the U.S.

"Light" olive oil is a marketing concept and not a classification of olive oil grades. It is completely unregulated by any certification organizations and therefore has no real precedent to what its content should be. Sometimes, the olive oil is cut with other vegetable oils.

My 3er. Secret

Only one intervention has been proven to extend both the average and maximum lifespan of all animal species tested: Reducing the consumption of dietary calories, or caloric restriction (CR).

While widely recommended, exercise and nutritional supplementation have not been shown to extend maximum lifespan.

Because CR extends maximum lifespan, scientists believe it actually slows the process of aging. CR is therefore used as a means to study the process of aging.

The graph to the left shows the lifespans of four groups of mice, illustrating the dramatic life extension induced by life-long CR. [8] The first group (green) were controls who ate freely without restriction and define normal lifespan. The other three groups were subjected to different degrees of CR initiated at one month of age, which is equivalent to a 2 year old child. Such early onset CR results in stunted growth and is therefore not acceptable for humans. The results found that more CR resulted in more life extension -- a pattern that holds until CR becomes actual starvation, whereupon it shortens lifespan. The graph is a two-frame animation. The second frame shows equivalent human lifespan.

Adult-onset CR: Only adult-onset-CR data are relevant for human consideration, and life extension is less when CR is initiated in midlife, approaching nil when initiated in late life. The next graphs show the lifespans of two long-lived mouse types gradually subjected to 44% (B10) and 27% (B6) CR starting at 12.5 months of age versus controls. B10 mice started CR at a human-age equivalence of 30, while B6 mice started CR at a human-age equivalence of 40. Note: Adult-onset CR extends animal life only when phased in gradually (over a period equivalent to 2.5 years in humans) and when augmented with a nutrient-enriched diet.

Caloric Restriction not only extends the lifespan of laboratory animals but also reduces the incidence of virtually all diseases of aging such as cancer, heart disease, diabetes, osteoporosis, auto-immune disorders, neurological decline and diseases such as Alzheimer's and Parkinson's.

Caloric Restriction has been shown to dramatically extend both the life and health of all animal species tested to date.[3]

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